The capabilities and experience in the discovery services have helped our clients accelerate their drug discovery programs. With a combination of 550 highly skilled scientists and a hi-tech set-up, we provide integrated chemistry services, including synthetic and medicinal chemistry, synthesis of a library of compounds from a few milligrams to a hundred-gram scale, or differentiated solutions for various drug discovery programs. We bring a track record of solving complex challenges across multiple therapeutic areas along with focused library search to fast-track discovery programs. The in-house capability to generate as well as procure proteins facilitate faster turn-around time for protein production.
Our Discovery Chemistry services extend from synthetic chemistry, library synthesis, peptide synthesis, PROTACs, and Oligonucleotides. The essential facilities at our centers provide the environment to generate and synthesize in-house, truncated proteins, and modified proteins that are not commercially available. The strong CADD team facilitates the hit identification by screening virtual libraries and is backed by strong analytical chemistry support, IT infrastructure, and competent data management systems.
With 40 modular labs including advanced analytical instruments, ranging from various synthesizers, NMR machines, and FT-IR, we provide the best-in-class medicinal chemistry services to various biotech, pharmaceutical, agrochemical, and specialty chemical companies.
As a leading CDMO company/contract research organization, we provide a wide range of medicinal chemistry offerings and customized services for pharma, biotech, animal health, and crop sciences.
Our offerings and services include:
Synthetic Chemistry Services
With the advanced synthetic chemistry methodologies and innovative route scouting design technologies, we provide a multi-gram quantity of high purity compounds to support your research needs across the discovery cycle.
Peptide Services:
Our dedicated team of experts has a track record of handling peptides ranging from simple linear peptides to polypeptides synthesis and its very complex forms from milligram to multi-gram quantities for advancing your discovery and developmental research needs.
Focused Library Synthesis:
We have two decades of vast experience in working with global clients in custom library synthesis of compounds and generating small to medium-sized custom libraries of target compounds.
PROTAC:
Expertise in the synthesis of PROTAC and partial PROTAC for targeted protein degradation, including the development and functionalization of various E3-ligase ligands such as CRBN, VHL, MDM2, and cIAP1, some of them even on the multi-gram scale.
Oligonucleotides:
We can synthesize 10-40-mer oligonucleotides up to 1 gram scale. We can perform all standard modifications, with or without backbone modification. We provide in-house capabilities for making any customized phosphoramidite.
Lipids:
Our highly experienced team of scientists perform various synthesis, characterization & biological evaluations of lipids ranging from 10 mg to 10 g scale.
Computational Chemistry Services:
The CADD/Bioinformatics teams at APSL work in tandem with chemistry and biology teams at every stage of the program. The CADD services facilitate the designing of molecules for various applications and aid in the discovery of new drugs with the help of advanced databases and software to support various projects.
We also have expertise in handling niche chemistry:
- Sensitive reactions ranging from milligrams to grams to kilogram scale
- Reaction temperatures from -78°C to 250°C
- Chiral chemistry ranging from chiral resolution and asymmetric synthesis
- Halogenation, nitration, sulfonation, and cyanation
- Organometallic chemistry expertise with LDA, n-BuLi, NaH, and NaNH2 reactions
- Reductions using borane, DIBAL, LiAlH4, NaBH4, Pd/C, and Pt2O reactions
- Suzuki, Buchwald, Mitsunobu, Friedel-Crafts, Wittig, Grignard reaction, etc.
- Photoredox Chemistry
Why Aurigene Discovery Chemistry Services?
90% of talent is PG or above
Integration of chemistry to biology & CDMO
State-of-the art facilities and modern infrastructure.
Data driven decision making- CADD, informatics, advanced software platforms
50K+ compound inventory management system
Integrated Services
Co-located Teams
20+ Years of legacy
Target identification to commercial manufacturing
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Pharmaceutical Analytical Services
Polymorph Screening
ADME/DMPK Services
Drug Formulation Services
In vivo Pharmacology
Medicinal Chemistry
Microbiology Testing
Peptide Synthesis
Development & Kilo Lab
Toxicology Studies
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Resources
JANUARY 04, 2021
Application of mPEGs in Drug Discovery and Development
Methoxy Polyethylene Glycols (mPEGs) are increasingly being applied in drug discovery and drug development to enhance the deliverability and bioavailability of the drug, and to increase the serum half-life. Today, due to advancements in chemical processes and purification techniques it is possible to produce high-quality mPEGs. mPEGs in combinati...
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Accelerating Drug Discovery Through Innovative Partnerships
Accelerating Drug Discovery Through Innovative Partnerships Genomics plays a vital role in identifying which gene is associated with a specific disease. A gene called CNOT1 is for example known for it's effect on brain development and for impairing memory and learning. Despite the great promise genomics provides in understanding the disease, gene...
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Custom Peptide Synthesis
Aurigene Pharmaceutical Services has decades of experience in providing services for peptide drug discovery, development and formulation manufacturing and is specialized in the synthesis of various types ...
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Technology meets sustainability - How a complex API development process goes green
We are always looking for ways to enhance the sustainability of our products and services. Our team successfully developed a scalable manufacturing process for the API product of one of our Biotech clients using eco-friendly manufacturing technologies. Read the case study to learn more. ...
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Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins
2013
The combination of CuI–K2CO3-PEG 400 facilitated the couplingcyclization of o-iodobenzoic acid with terminal alkynes under ultrasound, affording a greener and practical approach towards 3-substituted isocoumarins with remarkable regioselectivity. This inexpensive and Pd and ligand free methodology gave rise to various isocoumarins of potential pharmacological i...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2005
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2005
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Wang-OSO3H catalyzed green synthesis of bioactive isoindolo[2,1- a ]quinazoline-5,11–dione derivatives: An unexpected observation
2005
The sulphonic acid-functionalized Wang resin (Wang-OSO3H) was explored as a polymeric and recov- erable acidic catalyst for the synthesis of isoindolo[2,1- a ]quinazoline-5,11–dione derivatives under green conditions. Thus the Wang-OSO3H ...
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