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Viral Vectors Viral Vectors

Viral Vectors

We offer a diverse range of services in the area of viral vector generation for Cell and Gene Therapy (CGT).

The most effective method of gene transfer for modifying specific cell types or tissues is viral vector, which can be used for expressing therapeutic genes.

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Lentiviral vector system to develop producer cell lines (for difficult-to-express proteins)

  • Lentiviral system is useful when other transient expression systems viz. Expi / TranslT pro/ PEI yield low or negligible expression of target protein.
  • 10 to 100-fold higher titer as compared to transient expression
  • High stability of clones/ pool without selection pressure
  • Rapid selection resulting in faster TAT (4 - 6 weeks)
  • Cost effective

Lentiviral vector system to develop Reporter cell lines (GFP / RFP/ F-luc expressing cell lines)

  • Reporter cell lines are tools for in vitro / in vivo screening and efficacy evaluation
  • These cell lines (RFP/F-Luc) enable non-invasive detection and quantitation of subcutaneous, orthotopic, and metastatic xenografts in preclinical mouse models using bioluminescent imaging
  • Experience in generating orthotopic reporter cell lines for breast, prostate, melanoma, glioblastoma, colorectal, lung, and B-cell malignancies
  • In-house modified lentiviral vector system to develop reporter cell lines
  • Timelines: 12 - 16 weeks

Lentiviral vector system for generating Knock-down (KD) cell lines (SiRNA/ShRNA)

Knock-down cell lines are tools for in vitro / in vivo screening, binding studies, and efficacy evaluation and serve as disease models:

  • Single, double, or multiple gene knock-down of primary and established cell lines
  • Timelines: 12 - 16 weeks

Why Aurigene Viral Vectors Services?

Customized vector construction

State-of-the-art facilities

Regulatory audits and compliance to statutory norms

Team of scientists with extensive experience in viral vector generation

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Connect with our scientific experts for your drug discovery, development, and manufacturing needs

We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.

Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.

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