Our IDD team comprises medicinal chemists, computational chemists, biologists, pharmacologists, and toxicologists with extensive experience in delivering developmental candidates for clients. The key component of our IDD programs is a focused and dedicated team of experts, well-coordinated to deliver to clients expectations efficiently.
Our IDD platform spans across discovery and development of large and small molecules with the most effective and efficient means to conduct target validation, translational interrogation, therapeutic discovery, and preclinical development for our clients.
We have the capabilities to simultaneously apply multiple modalities for target validation and therapeutic discovery, as per specific target or pathway. With seamless integration into development stages, we offer a hassle-free outsourcing experience that is outcome driven and quality focused.
IDD services
We deliver a wide range of IDD services spanning chemistry, biology, DMPK, and toxicology to global clients based across diverse therapeutic areas. Our services seamlessly span the entire journey from early discovery to IND.
We offer an array of help in terms of project management and logistics. Our seasoned project management and senior scientific advisory services team adds value with insight and guidance for a smooth path to a development candidate.
Mix and Match programs
We provide mix and match services which includes the following service combinations:
- Medicinal chemistry + DMPK
- Medicinal chemistry design and synthesis: iterate design, synthesize and develop SAR
- Chemistry + DMPK + scale up
- Chemistry + DMPK + biology + toxicology
Why Aurigene Integrated Drug Discovery (IDD) Services?
18 years' experience in drug discovery
Various customer models: multi-year contract-based FTE models with big pharma as well as rapid hit
100+ discovery programs
Track record of delivering 8+ IND candidates
Speed: Our average candidate nomination time is 24-28 months
Capabilities to apply multiple modalities
Integrated project management
Various therapeutic modalities like oncology, anti-infectives, CNS & inflammation
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Resources
OCTOBER 01, 2024
PROTACs: Research for a life without cancer
PROTACs: Proteolysis-targeting chimeras (PROTACs) are a rapidly evolving field with promising applications in cancer, neurodegenerative diseases, and other conditions where the regulation of protein levels is crucial. PROTACs are a novel class of small molecules designed to target specific proteins for degradation by the ubiquitin-proteasome sys...
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Advancement in personalized medicine and how the CRDMO industry is part of the solution
Personalized medicine is transforming the healthcare landscape by customizing treatment plans to individual patients’ unique genetic, clinical and environmental characteristics. These are effective and less invasive treatments for a wide range of conditions. Contract Research, Development and Manufacturing Organizations (CRDMOs) play an important role...
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Cell Line Development
We enable development of stable and high yielding recombinant Mammalian and Microbial lines. ...
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Case study: Tackling CYP 2C9 inhibition challenges
The Problem: Active compounds in a project were found to be highly potent inhibitors of CYP 2C9 The compounds selectively inhibited CYP 2C9 with IC50 values <100 nM There was no considerable inhibition of the other CYP isoforms Our Mitigation Approach: CYP 2C9 inhibition data was generated for a larger set of co...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2022
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2005
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Wang-OSO3H catalyzed green synthesis of bioactive isoindolo[2,1- a ]quinazoline-5,11–dione derivatives: An unexpected observation
2005
The sulphonic acid-functionalized Wang resin (Wang-OSO3H) was explored as a polymeric and recov- erable acidic catalyst for the synthesis of isoindolo[2,1- a ]quinazoline-5,11–dione derivatives under green conditions. Thus the Wang-OSO3H ...
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Polycyclic Aromatic Compounds: A Simple and Efficient [(n-Bu3Sn)2MO4]n Catalyzed Synthesis of Quinazolinones and Dihydroquinazolinones
2005
A novel unprecedented approach for the synthesis of various quinazolinones and dihydroquinazolinones has been using [(n-Bu3Sn)2MO4]n as a catalyst. The reaction has been screened ...
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