GMP manufacturing capability supports any preclinical, clinical, and commercial scale manufacturing of a wide range of viral vector platforms – Lenti, Adeno, Retro, and Baculo.
Driven by scale flexibility, we can support on a wide scale of operation – 0.5L – 1,000L. Utilization of single-use technologies enable prompt change over by omitting cleaning validation.
We undertake an integrated approach to safety and quality management systems, which enable greater flexibility by leveraging pan – organizational experience in managing regulatory audits, and compliance to statutory norms.
Plasmid production and characterization
Lentivirus: Gag-pol, VSVG, Rev, and Transfer plasmids (3rd Gen system)
Recombinant adeno-associated virus (rAAV): Packaging plasmid (Rep-Cap), helper plasmid (VA-E2A-E4), and transfer plasmids
- GMP like
- Digestion and sequencing
Upstream process development
- HEK293T suspension / adherent
- Transfection (PEI or other methods)
- Shake flask, wave bioreactors, stirred-tank reactor, and iCELLis
Purification
Purification is done using ultracentrifuge or chromatography
- Clarification and concentration, TFF, and Benzonase
- Ultracentrifuge or chromatography (IEX, AEX, affinity, and SEC)
- Concentration and buffer exchange, TFF, and sterile filtration
QC and release
Release assay
- General/physical properties
- Identity
- Safety
- Purity
- Strength
- Potency
Viral Vaccine
Our viral vaccine manufacturing facility can cater to both – conventional and novel viral vaccines.
Our manufacturing capability (GMP/ Non-GMP) supports preclinical, clinical, and commercial scale manufacturing of a wide range of viral vaccines in suspension or combination of adherent and suspension methods.
We can support large- scale vaccine manufacturing – 2x1KL per batch run in a single-use platform. Manufacturing is supported by an in-house capability of viral vaccine development and MSAT.
Why Aurigene Viral Vectors Services?
2KL installed capacity
Low lead time to manufacturing.
30+ tech operation professionals
Zero liquid discharge capability
Integrated approach to safety and quality management systems
One-stop shop across the product life cycle – proof of concept to commercial
Integrated QC testing and release
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Resources
OCTOBER 01, 2024
PROTACs: Research for a life without cancer
PROTACs: Proteolysis-targeting chimeras (PROTACs) are a rapidly evolving field with promising applications in cancer, neurodegenerative diseases, and other conditions where the regulation of protein levels is crucial. PROTACs are a novel class of small molecules designed to target specific proteins for degradation by the ubiquitin-proteasome sys...
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Advancement in personalized medicine and how the CRDMO industry is part of the solution
Personalized medicine is transforming the healthcare landscape by customizing treatment plans to individual patients’ unique genetic, clinical and environmental characteristics. These are effective and less invasive treatments for a wide range of conditions. Contract Research, Development and Manufacturing Organizations (CRDMOs) play an important role...
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Cell Line Development
We enable development of stable and high yielding recombinant Mammalian and Microbial lines. ...
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Case study: Tackling CYP 2C9 inhibition challenges
The Problem: Active compounds in a project were found to be highly potent inhibitors of CYP 2C9 The compounds selectively inhibited CYP 2C9 with IC50 values <100 nM There was no considerable inhibition of the other CYP isoforms Our Mitigation Approach: CYP 2C9 inhibition data was generated for a larger set of co...
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Synthesis of Anti-covid Drug Nirmatrelvir Using Flow Chemistry
2022
Synthesis of the anti-covid therapeutic Nirmatrelvir by using flow chemistry to enhance efficiency of amide to nitrile conversion in a functionally and Stereochemically Embellished environment. ...
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Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
2005
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we obtained selective, cellularly active ...
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Wang-OSO3H catalyzed green synthesis of bioactive isoindolo[2,1- a ]quinazoline-5,11–dione derivatives: An unexpected observation
2005
The sulphonic acid-functionalized Wang resin (Wang-OSO3H) was explored as a polymeric and recov- erable acidic catalyst for the synthesis of isoindolo[2,1- a ]quinazoline-5,11–dione derivatives under green conditions. Thus the Wang-OSO3H ...
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Polycyclic Aromatic Compounds: A Simple and Efficient [(n-Bu3Sn)2MO4]n Catalyzed Synthesis of Quinazolinones and Dihydroquinazolinones
2005
A novel unprecedented approach for the synthesis of various quinazolinones and dihydroquinazolinones has been using [(n-Bu3Sn)2MO4]n as a catalyst. The reaction has been screened ...
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