Genotoxicity is an adverse effect of a chemical on genetic material via variety of mechanisms, including mutation. Genotoxicity testing is very crucial to determine potential carcinogenic or mutagenic compounds that can cause genetic alterations in somatic or germ cells, and this information is used in regulatory decision-making. Mutagenicity (gene mutation and structural and numerical chromosomal alterations) is one of the six basic testing areas that have been adopted by the Organization for Economic Co-operation and Development (OECD, 2011) as the minimum requirement to screen high-production volume chemicals for toxicity.
We provide a combination of tests to assess three major endpoints of genetic damage
- Gene mutation (i.e. point mutations or deletions or insertions that affect single or blocks of genes)
- Clastogenicity (i.e. structural chromosome changes)
- Aneuploidy (i.e. the occurrence of one or more extra or missing chromosomes, leading to an unbalanced chromosome complement).
In vitro genotoxicity testing
- Bacterial reverse mutation test (OECD 471)
- In vitro chromosomal aberration test using human blood lymphocytes (OECD 473)
- In vitro micronucleus test using human blood lymphocytes (OECD 487)
- Mammalian cell gene mutation assay (OECD 490)
Why Aurigene In vitro Genotoxicity Testing Services?
Combination of tests to assess genetic damage
State-of-the-art facilities
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Bangalore R and D Center
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Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
Resources
OCTOBER 01, 2024
PROTACs: Research for a life without cancer
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Wang-OSO3H catalyzed green synthesis of bioactive isoindolo[2,1- a ]quinazoline-5,11–dione derivatives: An unexpected observation
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The sulphonic acid-functionalized Wang resin (Wang-OSO3H) was explored as a polymeric and recov- erable acidic catalyst for the synthesis of isoindolo[2,1- a ]quinazoline-5,11–dione derivatives under green conditions. Thus the Wang-OSO3H ...
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Polycyclic Aromatic Compounds: A Simple and Efficient [(n-Bu3Sn)2MO4]n Catalyzed Synthesis of Quinazolinones and Dihydroquinazolinones
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