DMPK

Our expertise in wide range of DMPK studies provide our clients with customized, innovative and integrated drug discovery solutions with quick turnaround times.

Our DMPK team is having expertise in both integrated drug discovery and standalone DMPK services with experience over 16 years. Our capabilities helped us to deliver more than 65 IDD projects. We design customized protocols and perform assays based on client or project requirements. The DMPK facility spanning an area of 10,000 sq.ft. in Bangalore and Hyderabad locations consists of state-of-the-art in vitro ADME and tissue culture labs, AAALAC accredited animal facility for in vivo PK studies in rats, mice & dogs and GLP & Non-GLP bioanalytical labs with high-end LC-MS/MS instruments.

In vitro ADME capable of high-throughput screening with best in industry turnaround times. In vivo PK studies with various established surgical models. Experience in DMPK studies and bioanalysis of small molecules, PROTACs, therapeutic peptides and biomarkers. Automated compound management and data handling systems.

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DMPK Studies

Physicochemical Parameters
Metabolism Studies
Permeability
Distribution
Drug-drug Interactions
Pharmacokinetics
Bioanalysis

Physicochemical Parameters

Kinetic, high-throughput and thermodynamic solubility at different pH, SIF and SGF
Chemical stability at various pH, SIF and SGF
Log D, Chrom Log D

Metabolism Studies

Clearance in microsomes, hepatocytes, S9
Phase I and II metabolism, glucuronidation, glutathione, sulfation
Stability in plasma, blood
CYP phenotyping
Metabolite identification

Permeability

Caco-2 bi-directional permeability and efflux ratio
MDCK (native), MDCK-MDR1, MDCK-BCRP
PAMPA

Distribution

Plasma protein and in vitro tissue binding
Blood to plasma partition
Brain to plasma partition

Drug-drug Interactions

CYP inhibition, CYP TDI and kobs
CYP induction
P-gp and BCRP inhibition and substrate identification

Pharmacokinetics

PK in Rodents (rats/ mice): Single/ multiple-dose, discrete/ cassette, micro sampling, cross-over/ non-cross-over design
Single/multiple-dose PK in Beagle dogs
Tissue distribution, brain penetration, excretion, food effect, gender effect and dose escalation studies in rodents using the cold compound
Surgical models: Cannulations of single or double Jugular vein, tail vein, duodenum, bile duct, and femoral vein in rat

Bioanalysis

In vitro DMPK assays - generic gradient method
In vivo PK, PK/PD and TK
GLP compliant, state-of-the-art bio analytical lab to support
Bio-analytical method validation
Pharmacokinetics and tissue distribution studies
Toxicokinetic studies

Why Aurigene ADME/DMPK Services?

Turnaround time: In vitro Assays: 5 working days. In vivo PK Studies: 7 working days

Quality & accuracy

Customized protocols

Compound management and data automation

Broad panel of in vitro ADME & in vivo PK study designs

Bioanalysis of small molecules, therapeutic peptides, biomarkers & complex molecules. Delivered 200+ GLP studies

Other Services

GLP Toxicology and Non-GLP Toxicology Studies Services

In vitro Biology

In vivo Pharmacology Studies and Services

Pharmaceutical Microbiology Testing

Virtual Tour

Hyderabad R and D Center

Bangalore R and D Center

Connect with our scientific experts for your drug discovery, development, and manufacturing needs

We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.

Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.

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Frequently asked questions

Why is ADME important?

ADME data helps scientists assess and optimize the absorption, distribution, metabolism, and excretion of the drug/NCE early in the drug discovery process. This helps to minimize late-stage failures in in-vivo safety and efficacy studies and clinical trials.

What is ADME testing?

ADME testing involves various in-vitro and in-vivo assays used to assess the properties that determine the Absorption, Distribution, Metabolism, and Excretion (ADME) of NCEs/ drug molecules.

What is the ADME process?

The ADME process involves the characterization of a drug by using different assays to determine its absorption, distribution, metabolism, and excretion properties. This data is critical to prioritize and advance drug/ NCEs for future development.

What is DMPK in drug discovery?

DMPK is the study of the drug-like properties of new chemical entities(NCE)/drugs to understand its metabolism and pharmacokinetic profile.

What is the purpose of a PK study?

PK studies are an integral part of drug development. It helps to understand a new chemical entity (NCEs)/drug's pharmacokinetic behaviour in the body and involves the study of distribution, metabolism, clearance and bioavailability.

What is the difference between PK and PD?

Pharmacokinetics (PK) is the response of the body to the drug. Whereas Pharmacodynamics (PD) is the action of the drug on our body.

What are the recommended storage conditions for Oligonucleotides?

For a period of 6 weeks, Oligos can be stored in T10E1 buffer at 37°C and for the long term, Oligonucleotides can be dried down and stored with or without TE buffer at -20°C.

What is pharmacodynamics of a drug?

Pharmacodynamics (PD) of a drug refers to the biochemical and physiological effects caused by the drug/NCE in the body.

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DMPK

DMPK Studies

Physicochemical Parameters

Metabolism Studies

Permeability

Distribution

Drug-drug Interactions

Pharmacokinetics

Bioanalysis

Why Aurigene ADME/DMPK Services?

Other Services

GLP Toxicology and Non-GLP Toxicology Studies Services

In vitro Biology

In vivo Pharmacology Studies and Services

Pharmaceutical Microbiology Testing

Pharmaceutical Microbiology Testing

Virtual Tour

Connect with our scientific experts for your drug discovery, development, and manufacturing needs

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Resources

The Journey from Scientific to patient impact

End-to-End Rebuild of a Complex Bicyclic Peptide Synthesis

Identification of Degradants of Thermal and Oxidation Stress Studies of Empagliflozin and Linagliptin Tablets by HPLC-PDA and LC-MS Instrumental Techniques

Frequently asked questions

Why is ADME important?

What is ADME testing?

What is the ADME process?

What is DMPK in drug discovery?

What is the purpose of a PK study?

What is the difference between PK and PD?

What are the recommended storage conditions for Oligonucleotides?

What is pharmacodynamics of a drug?

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