Role of Peptide Synthesis Based Drugs

• Identification of specificity/potency by truncation of N-terminal/ C-terminal sequences
• Identification of critical residues or stabilizing motif by Ala Scan, Lactam Scan and Cysteine Scan
• Fragment stabilization/PK profile improvement by suitable substitution of amino acids, D-amino acids / inverso sequences, retro-inverso, lipidation/ conjugation, PEGylation, conformationally constrained peptides, backbone modification; peptido-mimetics, etc.

Classes of custom peptide synthesis based drugs in treating diseases

• Anti-microbial Peptides (AMPs) – are used to treat a broad range of microbial infections and may also be used in treating fungal infections. Once they enter the membrane they may cause a toroidal, carpet or a barrel-stave pore and kill the infection causing agents.
• Anti-angiogenic Peptides (AAPs) – are used to treat a wide range of cancers. They help by inhibiting the angiogenic process thus stopping multiplication of new blood vessels.
• Anti-inflammatory Peptides (AIPs) – occur naturally in all living organisms to reduce inflammation. AIPs may act by inhibiting, reducing, or modulating the expression and/or activity of mediators.
• Anti-appetizing Peptides – are a family of peptides used to treat obesity. They act by suppressing hunger and thus reducing weight gain.
• Anti-thrombotic Peptides – are useful against the formation of blood clots in the body. Anti-thrombotic peptide may be used in the prevention and treatment of life threatening blood clots.
• Opioid Peptides - are a set of peptides that have the ability to bind with the target opioid receptors. They may be used to manage pain and may be used for substance abuse de-addiction therapy.