Antibody Drug Conjugate Services
Antibody, linker-payload, conjugation and analytics – we provide a one-stop solution for ADC discovery and development
We understand the dynamic nature of the current ADC technology landscape and the complexities associated with it. Our team is well versed with a wide range of ADC technologies and is capable of adopting new technologies to support our client needs. We also provide expertise to develop novel liker technologies and cytotoxic payload optimization.
Linker Technologies:
We offer ADC linkers based on their drug release mechanism
- Cleavable and non-cleavable linkers
- Self-immolative tracer free linkers
- Peptide linkers
Conjugation technologies:
- Amine (Lys) conjugation
- Thiol (Cys) conjugation
- Site specific conjugation
- Enzymatic conjugation
Payloads:
- Cytotoxic, non-cytotoxic and biologic payloads
- Classes of cytotoxic payloads handled: Autistatins (MMAE & MMAF), Tubulysin, PBD dimer, Maytansin (DM1), Duocarmycin, SN38, etc.
ADC Discovery and Development:
Discovery programs are customized keeping the target biology and mechanism of action in mind. Specific screening strategies are designed and employed at a stage as early as antibody generation. Some of the early stage activities include screening and design of mAbs for internalization (or lack of it), effector function, off-site localization, half-life, etc. Rapid and comprehensive scouting of the linker-payload technology space can be plugged-in to identify the most desirable combinations of mAb, linker-payload and conjugation strategies. Stage appropriate in vitro screening and detailed evaluation of lead ADC molecules is carried out using customized assay platforms. We also provide in vivo therapeutic evaluation, PK and rodent toxicology assessment support for ADC candidates with appropriate bioanalytical methods customized for each program. Conjugation and purification process development takes into account each component of the ADC molecule. Quality, scalability, safety and cost-effectiveness concerns are addressed at each stage of process development.
ADC Analysis
A biomolecule is complex as an ADC and demands through analytical assessment to ensure safety and quality.
Routinely Determined Attributes are:
- Aggregation
- Fragmentation
- Free-drug
- DAR average
- Conjugation site
- Endotoxin
- Antigen binding affinity
- In vitro potency
Virtual Tour
Hyderabad R and D Center
Bangalore R and D Center
Pharmaceutical Analytical Services
Polymorph Screening
ADME/DMPK Services
Drug Formulation Services
In vivo Pharmacology
Medicinal Chemistry
Microbiology Testing
Peptide Synthesis
Development & Kilo Lab
Toxicology Studies
Connect with our scientific experts for your drug discovery, development, and manufacturing needs
We understand that clear communication is essential to successful collaborations, and that's why we have a dedicated team that is always ready to help you. Whether you have questions about our services, want to discuss a potential partnership, or simply want to learn more about our company, we're here to help.
Our team of experts is dedicated to providing personalised solutions tailored to your unique needs. So, please don't hesitate to reach out to us. We look forward to hearing from you and helping you achieve your business goals.
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