Pharmacokinetic Studies

Our pharmacokinetic (PK) studies in rats, mice, and dogs help in understanding the characteristics of a potential NCE. Our PK studies are highly efficient in predicting the exposure while determining the dosage levels and frequencies for testing in preclinical in vivo animal disease efficacy models. We conduct PK studies for small and large molecules at our state-of-the-art laboratories and vivarium. Our DMPK scientists help understand the drug's AUC, clearance, half-life, the volume of distribution, Cmax, and Cmin in the body over time.

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Why is pharmacokinetics important in drug discovery?

The characteristic study of pharmacokinetics of drugs in drug development is crucial to ensure its safety and efficacy along with optimizing its ADME properties and other parameters to achieve the desired clinical efficacious candidate.

What is the purpose of pharmacokinetic studies in APSL?

Pharmacokinetic studies in APSL are carried out to assess the potency of the drug compound by examining the parameters on elimination, half-lives, and ADME properties and help scientists to design safer pre clinical and clinical trials.

What is the process followed during pharmacokinetic studies in APSL?

The standard pharmacokinetic process involves characterizing the potential drug by studying the ADME parameters. Depending upon the single or repeated dose the blood and urine samples are analyzed to determine exposure, dose levels, and preclinical testing.

What are the parameters considered during pharmacokinetic studies in APSL?

Pharmacokinetic studies in animals involve validating the necessary parameters on ADME along with clearance studies, half-life, bio availability, volume of distribution, and protein drug interactions.

What are the benefits of pharmacokinetic studies?

Pharmacokinetic study validates and ensures the safety and efficacy of drugs during pre-clinical and clinical trials by analyzing the ADME properties. It also provides data regarding drug-drug interactions and the disposition of a drug.

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Pharmacokinetic Studies